Mesenchymal Stem Cells (MSCs) are proving to be an important player in regenerative medicine. MSCs have been isolated from various tissue including bone marrow, adipose tissue and umbilical cord. In both pre-clinical and clinical studies, MSCs isolated from Wharton Jelly of the umbilical cord have shown immunomodulatory functions which have been attributed to their immune-privileged state due to their embryonic origin. The therapeutic potential of MSCs have been found, in addition to the cells also in the conditioned media as well as extracellular vesicles secreted by MSCs. At I3T, we are engaged in MSC biology of the Wharton Jelly and are interested in the multiple mode of therapeutic intervention. Understanding the role of MSCs in musculoskeletal processes such as fracture repair, osteoarthritis and muscle and fat related disease condition will be essential to harness the regenerative capacity of MSCs and provide solutions for unmet need of patients.