Typhoid

Typhoid is a bacterial infection that can lead to a high fever, diarrhoea, and vomiting. It can be fatal. It is caused by the bacteria Salmonella typhi. Typhoid fever is an infection that spreads through contaminated food and water. Vaccines are recommended in areas where typhoid fever is common. Symptoms include high fever, headache, stomach pain, weakness, vomiting and loose stools. Treatment includes antibiotics and fluids.

Why I3T Focuses on that:

Typhoid, the enteric fever, caused by the gram-negative bacteria Salmonella Typhi, imposes severe threat to public health in countries with poor sanitation system management and limited access to clean water supply. Copious occurrence of the above factors in south-east Asia and sub-Saharan Africa renders the population of these zones prone to Typhoid causing a notable amount of death and disability, especially among children. Transpiration of the multi-drug resistant bacterial strains has increased the possibility of fast spreading of the disease in the overcrowded populations with poor liquid sewerage system. Prior to prequalify the Typhoid conjugate vaccine in December 2017, the Strategic Advisory Group of Experts (SAGE) of World Health Organization (WHO) had recommended the use of Typhoid conjugate vaccines in children (6 months -2 years) with an additional campaign extending the range of age up to 15 years in October of the same. Despite these efforts the burden of enteric fever stands quite tall, especially in the Indian scenario.

We set our sight to probe thorough investigation to ascertain mechanism undermining drug resistance, post-infection host metabolism, development of prophylactic schemes and identification of bacterial strains.