Malaria and Dengue

These are very common but deadly diseases caused by a plasmodium parasite, transmitted by the bite of infected mosquitoes. There are four kinds of malaria parasites that can infect humans: Plasmodium vivaxP. ovaleP. malariae, and P. falciparum.Dengue viruses are spread to people through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito.

Why I3T Focuses on that:

I3T research Scientists want to understand how the dengue virus causes damage to the human body and how the immune system responds to a dengue infection so that they can develop new treatments for the disease.

Dengue is perhaps the commonest among the vector-borne infections worldwide. Worldwide, about 390 million cases are estimated per year, of which 96 million are reported clinically.   Four serotypes of dengue virus (DENV), the causative pathogen, have been reported till date. The virus is transmitted by arthropod mosquito vector of Aedes species (Ae. aegypti  and Ae. albopictus). Ae. aegypti  has a widespread distribution in many urban and rural parts of India and is predominant as dengue vector here. Malaria, another fatal communicable disease, poses significant threat to public health, especially in south-east Asia, sub-Saharan Africa, and tropical area of central and South America. As per the recent report from WHO, the global case burden and death count are estimated to be around 229 million and 409 thousand, respectively. India, with about 5.6 million cases, accounts for almost 90% of the total caseload with similar mortality percentage for south-east Asia region.

I3TK seeks to buttress the elaborated investigation on these communicable diseases to elucidate the yet-unidentified host-pathogen interaction mechanism, post-infection hosts’ physiological response, and development of ‘state-of-the-art’ cure armamentarium including suitable prophylactic measure.