{"id":10879,"date":"2021-10-01T06:03:43","date_gmt":"2021-10-01T06:03:43","guid":{"rendered":"https:\/\/i3tk.org\/demo2\/?p=10879"},"modified":"2021-10-01T06:03:46","modified_gmt":"2021-10-01T06:03:46","slug":"preventive-treatment-reduces-diabetic-retinopathy-complications","status":"publish","type":"post","link":"https:\/\/i3tk.org\/demo2\/world-news\/resources\/preventive-treatment-reduces-diabetic-retinopathy-complications\/","title":{"rendered":"Preventive treatment reduces diabetic retinopathy complications"},"content":{"rendered":"\n

In a clinical trial, early treatment with anti-vascular endothelial growth factor (VEGF) injections slowed diabetic retinopathy, a complication of diabetes that causes damage to the blood vessels of the light-sensitive tissue in the retina. However, two years into the four-year study, the early treatment\u2019s effect on vision \u2013 including changes in visual acuity and vision loss – was similar to standard treatment, which usually begins only after the onset of late disease. The intermediate findings from the DRCR Retina Network (DRCR.net) published today in JAMA Ophthalmology. The study was supported by the National Eye Institute (NEI), a part of the National Institutes of Health.<\/p>\n\n\n\n

\u201cWhile it is possible that preventive injections of anti-VEGF drugs may help protect vision in the longer-term, we saw no effect on vision at two years,\u201d said Raj Maturi, M.D., Indiana University, Indianapolis, the protocol chair for the study. \u201cThese two-year results suggest that close monitoring and routine treatment when complications develop are key to preventing vision loss from diabetic retinopathy.\u201d<\/p>\n\n\n\n

An estimated 30 million Americans have diabetes<\/a>, which can cause blood vessel abnormalities, including the growth of new blood vessels in the eye. In the early stages of diabetic retinopathy, called non-proliferative diabetic retinopathy, changes in the eye\u2019s blood vessels are visible to clinicians but generally do not affect sight. In the advanced stages, people can develop proliferative diabetic retinopathy,  where retinal blood vessels grow abnormally, and\/or diabetic macular edema, where fluid leaks out of the retinal blood vessels. Both can lead to vision loss and blindness. Treatment, such as with anti-VEGF drugs, can slow or prevent vision loss in people with proliferative diabetic retinopathy or diabetic macular edema, if treatment occurs promptly.<\/p>\n\n\n\n

In this study, participants with non-proliferative diabetic retinopathy were randomly assigned at baseline to receive either injections of Eylea (aflibercept) or a sham injection. They were examined at one, two, and four months, and then every four months for two years, receiving Eylea or sham injection at each visit. The researchers tracked their visual acuity and the severity of their diabetic retinopathy. If disease progressed, regardless of whether they were in the treatment or sham group, participants were given Eylea more frequently as is given in standard practice. If their condition did not improve with additional anti-VEGF treatment, participants could be given treatments such as laser photocoagulation or surgery if necessary.<\/p>\n\n\n\n

The study included 328 participants (399 eyes). In two years, the rate of proliferative diabetic retinopathy development was 33% in the control group, compared with 14% in the treatment group. Likewise, the rate of development of diabetic macular edema affecting vision was 15% in the control group, compared with 4% in the treatment group. However, loss of visual acuity was essentially the same between the two groups at two years, suggesting that standard treatment at the appearance of proliferative diabetic retinopathy or diabetic macular edema affecting vision is sufficient to prevent further vision loss at this time point.<\/p>\n\n\n\n

\u201cWe have a really good treatment for these diseases, so we can manage vision complications that may arise as disease progresses for many eyes,\u201d said Adam Glassman, Jaeb Center for Health Research, Tampa, Florida, director of the DRCR.net coordinating center. \u201cWhen evaluating new preventative treatment strategies, it is important to compare them directly to the standard treatment after disease worsens, as we have done in this study.\u201d<\/p>\n\n\n\n

\u201cAlthough we did not see any difference in visual outcomes at two years, the four-year follow-up is going to be very important,\u201d said Jennifer Sun, M.D., M.P.H., Joslin Diabetes Center, Harvard Medical School, Boston, chair of Diabetes Initiatives for the Network. \u201cWe look toward the four-year data to see whether reducing rates of diabetic retinopathy worsening will lead to long-term improvement in visual outcomes.\u201d<\/p>\n\n\n\n

The Clinicaltrials.gov identifier for this study is NCT02634333<\/a>. The study was supported by NEI and the National Institute of Diabetes and Digestive and Kidney Diseases, with funding through the Special Diabetes Program, through a cooperative agreement (EY14231). Regeneron provided aflibercept for the study and funds to DRCR Retina Network to defray the study\u2019s clinical site costs. JDRF also provided funds to defray clinical site costs.<\/p>\n\n\n\n

NEI leads the federal government\u2019s research on the visual system and eye diseases. NEI supports basic and clinical science programs to develop sight-saving treatments and address special needs of people with vision loss. For more information, visit https:\/\/www.nei.nih.gov<\/a>.   <\/p>\n\n\n\n

About the National Institutes of Health (NIH):<\/strong> NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

In a clinical trial, early treatment with anti-vascular endothelial growth factor (VEGF) injections slowed diabetic retinopathy, a complication of diabetes that causes damage to the blood vessels of the light-sensitive tissue in the retina.<\/p>\n","protected":false},"author":1,"featured_media":10884,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"class_list":["post-10879","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resources"],"yoast_head":"\nPreventive treatment reduces diabetic retinopathy complications - International Institute of Innovation and Technology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/i3tk.org\/demo2\/world-news\/resources\/preventive-treatment-reduces-diabetic-retinopathy-complications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preventive treatment reduces diabetic retinopathy complications\" \/>\n<meta property=\"og:description\" content=\"In a clinical trial, early treatment with anti-vascular endothelial growth factor (VEGF) injections slowed diabetic retinopathy, a complication of diabetes that causes damage to the blood vessels of the light-sensitive tissue in the retina.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/i3tk.org\/demo2\/world-news\/resources\/preventive-treatment-reduces-diabetic-retinopathy-complications\/\" \/>\n<meta property=\"og:site_name\" content=\"International Institute of Innovation and Technology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/International-Institute-of-Innovation-and-Technology-101979535699954\" \/>\n<meta property=\"article:published_time\" content=\"2021-10-01T06:03:43+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-10-01T06:03:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i3tk.org\/demo2\/wp-content\/uploads\/2021\/10\/colin-lloyd-suj3od1uMv8-unsplash.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"427\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@i3tkolkata\" \/>\n<meta name=\"twitter:site\" content=\"@i3tkolkata\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/world-news\\\/resources\\\/preventive-treatment-reduces-diabetic-retinopathy-complications\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/world-news\\\/resources\\\/preventive-treatment-reduces-diabetic-retinopathy-complications\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/#\\\/schema\\\/person\\\/2ed104da3b2d63ba12c40da792d0bf2e\"},\"headline\":\"Preventive treatment reduces diabetic retinopathy complications\",\"datePublished\":\"2021-10-01T06:03:43+00:00\",\"dateModified\":\"2021-10-01T06:03:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/world-news\\\/resources\\\/preventive-treatment-reduces-diabetic-retinopathy-complications\\\/\"},\"wordCount\":815,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/world-news\\\/resources\\\/preventive-treatment-reduces-diabetic-retinopathy-complications\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/wp-content\\\/uploads\\\/2021\\\/10\\\/colin-lloyd-suj3od1uMv8-unsplash.jpg\",\"articleSection\":[\"Resources\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/i3tk.org\\\/demo2\\\/world-news\\\/resources\\\/preventive-treatment-reduces-diabetic-retinopathy-complications\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/world-news\\\/resources\\\/preventive-treatment-reduces-diabetic-retinopathy-complications\\\/\",\"url\":\"https:\\\/\\\/i3tk.org\\\/demo2\\\/world-news\\\/resources\\\/preventive-treatment-reduces-diabetic-retinopathy-complications\\\/\",\"name\":\"Preventive treatment reduces diabetic retinopathy complications - 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