{"id":10810,"date":"2021-09-15T06:13:20","date_gmt":"2021-09-15T06:13:20","guid":{"rendered":"https:\/\/i3tk.org\/demo2\/?p=10810"},"modified":"2021-09-15T06:18:34","modified_gmt":"2021-09-15T06:18:34","slug":"plasma-may-do-more-harm-than-good-study","status":"publish","type":"post","link":"https:\/\/i3tk.org\/demo2\/world-news\/resources\/plasma-may-do-more-harm-than-good-study\/","title":{"rendered":"Plasma may do more harm than good: Study"},"content":{"rendered":"\n<p>Mumbai: A study led by Canadian researchers has proved what was feared all along by many Indian medical experts: convalescent&nbsp;<a href=\"https:\/\/health.economictimes.indiatimes.com\/tag\/plasma+therapy\">plasma therapy<\/a>&nbsp;may do more harm than good.<\/p>\n\n\n\n<p>Nearly 36,000 people in the state are believed to have been treated with convalescent&nbsp;<a href=\"https:\/\/health.economictimes.indiatimes.com\/tag\/plasma\">plasma<\/a>&nbsp;through the two Covid waves. Pune division saw the highest use, followed by Nagpur and Konkan.<\/p>\n\n\n\n<p>The&nbsp;<a href=\"https:\/\/health.economictimes.indiatimes.com\/tag\/concor-1+trial\">CONCOR-1 trial<\/a>&nbsp;published in Nature Medicine journal found that plasma therapy, one of the most hyped treatments, was ineffective in reducing the risk of intubation (going on&nbsp;<a href=\"https:\/\/health.economictimes.indiatimes.com\/tag\/ventilator\">ventilator<\/a>) or death. Worse, recipients of the blood product (33%) had significantly more serious adverse events, including increased oxygen requirement and respiratory failure, than those who got standard care (26.4%). Intubation or death occurred among 32.4% patients treated with plasma, over 28% who did not get it.<\/p>\n\n\n\n<p>The other crucial learning was that variable antibody levels in patients and plasma donors affected the treatment response. \u201cPlasma found to have either low or non-functioning antibody levels was associated with a greater risk of intubation or death,\u201d the study found. The \u201cpoor\u201d antibodies in plasma may compete with a patient\u2019s functioning antibodies to derail the&nbsp;<a href=\"https:\/\/health.economictimes.indiatimes.com\/tag\/immune+response\">immune response<\/a>, the researchers believed.<\/p>\n\n\n\n<p>\u201cIt has been thought that the blood plasma of Covid-19 survivors would help those seriously ill from the virus but, unfortunately, it does not,\u201d Donald Arnold, a professor at McMaster University in Canada and co-principal investigator of the study, told PTI.<\/p>\n\n\n\n<p>Demand for plasma touched the skies during the first wave as patients shelled out up to Rs 60,000 for a single unit. The euphoria subsided when the Indian Council of Medical Research (ICMR) revealed last year its trial findings that plasma was not that effective. But it didn\u2019t disappear as the private sector continued its indiscriminate use. ICMR removed it from its treatment protocols only this May.<\/p>\n\n\n\n<p>Maharashtra announced its own trial, Platina project, on 150 critical patients as well as for distribution of plasma for emergency use. It was stopped in January as it was found to be detrimental, said Dr Mohammed Faisal, nodal officer, adding that the findings will be published.<\/p>\n\n\n\n<p>According to the Maharashtra FDA, 34,874 units of plasma were distributed across districts. A total of 19,631 people had donated 36,246 bags of plasma. Since the ICMR removed it from treatment protocol, they have stopped keeping records, said an official. The state has no data on deaths caused by adverse events of plasma.<\/p>\n\n\n\n<p>Dr Vasant Nagvekar, a member of the state Covid task force, said with monoclonal antibodies, the use of plasma has almost stopped.<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img class=\"lazyload\" decoding=\"async\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27359%27%20height%3D%27225%27%20viewBox%3D%270%200%20359%20225%27%3E%3Crect%20width%3D%27359%27%20height%3D%27225%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/etimg.etb2bimg.com\/photo\/86216605.cms\" alt=\"Plasma may do more harm than good: Study\" width=\"359\" height=\"225\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>A study led by Canadian researchers has proved what was feared all along by many Indian medical experts: convalescent plasma therapy may do more harm than good.<\/p>\n","protected":false},"author":1,"featured_media":10322,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"class_list":["post-10810","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-resources"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v18.8 (Yoast SEO v27.4) - 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